HEPATOPROTECTIVE ACTIVITY OF ECLIPTA ALBA PDF

Government college of pharmacy, Bangalore Abstract: Eclipta alba L. The herb has been known for its curative properties and has been utilized as antimytotoxic, analgesic, antibacterial, antihepatotoxic, antihaemorrhagic, antihyperglycemic, antioxidant, immunomodulatory properties and it is considered as a good rejuvenator too. A wide range of chemical compounds including coumestans, alkaloids, thiopenes, flavonoids, polyacetylenes, triterpenes and their glycosides have been isolated from this species. Extracts and metabolites from this plant have been known to possess pharmacological properties. This contribution provides an comprehensive review on ethnomedicinal uses, chemical composition, and the pharmacological profile as medicinal plant. Particular attention is given to antihepatotoxic, analgesic, antioxidant , antihyperglycemic, antiaggresive, wound healing properties and insecticidal effects presented in this review such that the potential use of this plant either in pharmaceutics or as an agricultural resource can be evaluated.

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Abstract Background: The hepatic injury due to oxidative stress was ameliorated through administration of an aqueous extract of Eclipta alba leaves and suggested that wedelolactone and demethylwedelolactone were the possible components of Eclipta alba behind the protective effect on liver as well as against liver disorders. Objective: To study the hepato-protective effects of Eclipta alba on high fatty diet treated experimental models.

Material and methods: A total of 30 adult albino rats of Wistar strain weighing grams, from the animal house of the Basaveshwara Medical College, Hospital and Research Centre, Chitradurga, were used for the present study: group 1 included animals fed with normal diet control ; group 2, animals treated with hyperlipidemic diet for eight weeks; group 3, animals treated with hyperlipidemic diet for eight weeks, followed by one week post treatment of Eclipta alba with normal diet; group 4, animals treated with hyperlipidemic diet for eight weeks, followed by two weeks post-treatment of Eclipta alba with normal diet; and group 5, animals treated with hyperlipidemic diet for eight weeks, followed by three weeks posttreatment of Eclipta alba with normal diet.

Conclusion: The components of Eclipta alba like wedelolactone, demethylwedelolactone and saponins reduced fat deposition, mononuclear infiltration, and necrotic foci, and stimulated hepatocyte regeneration in the liver. Keywords:high fat diet, mononuclear infiltration, necrotic foci, Eclipta alba, liver pathology. It is related to insulin resistance and the metabolic syndrome obesity, combined hyperlipidemia, diabetes mellitus type II and high blood pressure 1, 2. Non-alcoholic fatty liver disease is also more common among men than women in all age groups until the age of 60, where the prevalence between sexes becomes equal.

This is due to the protective nature of estrogen 5. Eclipta alba L. The present study was undertaken to study the hepato-protective role of Eclipta alba against high fatty diet treated animals.

The animals were fed with standard rat pellet diet commercially available and manufactured by the National Institute of Nutrition, Hyderabad and clean drinking water ad libitum. Rats were divided into five groups, each consisting of six animals. Preparation of Extract Dried roots of Eclipta alba were charged to a Soxhalate apparatus along with water. This process was repeated. Extracts were then combined and filtered.

The resulted product was charged to a drier unit to convert it into a powder form, which was further powdered in a multimill to a fine mesh size. Afterwards, it was sieved using a Sifter, to obtain uniform particle sizes, and then mixed in a blender to become uniform and homogenous. It was packed in food grade, virgin, double polythene bags, and the whole process was repeated.

Animal grouping Group 1: Animal fed with normal diet Control. Group 2: Animals treated with hyperlipidemic diet for eight weeks. Group 3: Animals treated with hyperlipidemic diet for eight weeks, followed by one week post-treatment of Eclipta alba with normal diet. Group 4: Animals treated with hyperlipidemic diet for eight weeks, followed by two weeks post-treatment of Eclipta alba with normal diet.

Liver specimens were processed for routine histopathological examination to study the structural changes in liver of obese Albino rats fed on high fat diet. Does the above mean that the Provisions of the Mosaic Law are of no value or obsolete in the new, after Christ, reality? According to Apostle Paul see 1 Timothy ; Colossians , the Provisions of the Mosaic Law are based on human commands and teachings and thus are of no value for the man or woman renewed in Christ, and furthermore are not enacted for the righteous, but for the lawless and rebellious persons, as prostitutes.

It is important to note that according to Christian teaching, marriage is psychosomatic and not only a somatic union of a man and a woman cf. Genesis ; it is a society of human faces and persons, whose main purpose is mutual completion and their perfection 8.

Moreover, such contact does not usually lead to childbirth see the medical approach below. We point out that in addition to Judaism and Christianity , Islam also forbids men to have vaginal sexual intercourse with their wives during menstruation. Say, it is harm, so keep away from wives during menstruation. And do not approach them until they are pure. And when they have purified themselves, then come to them from where Allah has ordained for you. Medical Approach On histopathological examination, animals in the control group showed hexagonal hepatic lobules with central vein, portal triad, Kupffer cells and radiating cords of polyhedral hepatocytes, sinusoids in liver Fig.

Histopathological changes in experimental group animals Animals treated with hyperlipidemic diet for eight weeks Group 2 showed dilated central vein, deposition of adipocytes more in the periportal area, scattered in between the hepatocytes, fat lobules and degenerated hepatocytes in the liver parenchyma Fig.

Animals treated with hyperlipidemic diet for eight weeks, followed by one week post treatment of Eclipta alba with normal diet Group 3 showed less dilation of the central vein, deposition microvescicular fat, some degenerated hepatocytes and few fatty lobules Fig.

Animals treated with hyperlipidemic diet for eight weeks, followed by two weeks post-treatment of Eclipta alba with normal diet Group 4 showed few adipocytes around the central vein and in between the hepatocytes Fig. In animals treated with hyperlipidemic diet for eight weeks, followed by three weeks posttreatment of Eclipta alba with normal diet Group 5 we observed normal hepatocytes, portal triad, normal central vein, portal triad, few mononuclear infiltration, normal Kupffer cells and sinusoids in the liver Fig.

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